WHO recommends two monoclonal antibody drugs to treat Ebola

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The World Health Organization (WHO) on Friday recommended two monoclonal antibody treatments for Ebola, saying the use of these drugs combined with better care had ‘revolutionized’ the treatment of a disease once considered near death. certain.

The drugs — Regeneron’s Inmazeb (REGN-EB3) and Ridgeback Bio’s Ebanga (mAb114) — use lab-made monoclonal antibodies that mimic natural antibodies to fight infections.

DEADLY MARBURG VIRUS LIKE EBOLA COULD ‘SPREAD FAR AND WIDE’ IF NOT STOPPED: WHO

Regeneron’s monoclonal antibody Inmazeb (REGN-EB3), developed using the same rapid response technologies as Regeneron’s COVID-19 drug, is one of two drugs WHO now recommends to treat the virus Ebola. Pictured: Men resuscitate an Ebola awareness poster in Tchomia, Democratic Republic of Congo, October 9, 2018.
(WHO/Aboulaye Cissé/Handout via REUTERS/Files)

“Advances in supportive care and therapies over the past decade have revolutionized the treatment of Ebola. Ebola virus disease was once seen as an almost certain killer. However, that is no longer the case,” said university professor Robert Fowler. of Toronto, Canada, and co-chair of the WHO guideline development group. Effective care and use of these treatments now lead to the “vast majority” of people being cured of Ebola, he said, without giving specific data.

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The new recommendations follow trials of drugs for hemorrhagic fever in the Democratic Republic of Congo during a 2018-2020 outbreak. Dr Janet Diaz, head of the clinical management unit of WHO’s health emergencies programme, told reporters the drugs were currently available in Congo but more work was needed to improve accessibility.

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